phosphodiesterase 3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1266	3-O-Methylquercetin		IL Receptor , cAMP , PDE
	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentr...		IL Receptor , cAMP , PDE
T21389	Enprofylline	Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum	Others
	Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sick...		Others
T5956	VP3.15 dihydrobromide		GSK-3 , PDE
	VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1.59 μM , 0.88 μM,respectively.)		GSK-3 , PDE
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T1713	IBMX	3-Isobutyl-1-methylxanthine,1-Methyl-3-Isobutylxanthine,Methylisobutylxanthine,Isobutylmethylxanthine	PDE
	IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM). IBMX enhances the intracellular cAMP level.		PDE
T16164	MY-5445	N-(3-chlorophenyl)-4-phenylphthalazin-1-amine	PDE
	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).		PDE
T17199	Udenafil		PDE
	Udenafil is an inhibitor of PDE5 .		PDE
T19706	Ro 20-1724	Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724	PDE
	Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.		PDE
T1096	Milrinone	Win 47203	PDE
	Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.		PDE
T0462	Cilostazol	OPC 21,OPC 13013	PDE , Autophagy
	Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.		PDE , Autophagy
T12267	NSP-805		PDE
	NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.		PDE
T19865	GEBR-7b	3-(Cyclopentyloxy)-4-methoxybenzaldehyde	PDE
	GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.		PDE
T1265	Amrinone	Inamrinone,Inocor,Wincoram	TNF , PDE
	Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.		TNF , PDE
T6644	Rolipram	SB 95952,ZK 62711,(R,S)-Rolipram	HIV Protease , Antibacterial , PDE
	Rolipram (SB 95952) is a phosphodiesterase 4 inhibitor with antidepressant properties.		HIV Protease , Antibacterial , PDE
T3465L	Vesnarinone HCl	Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)	Potassium Channel , Calcium Channel , PDE
	Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new...		Potassium Channel , Calcium Channel , PDE
T5033	Olprinone	Loprinone	PDE
	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ...		PDE
T0160	Anagrelide	Anagrelida,Xagrid,Anagrelidum	PDE
	Anagrelide (Xagrid) is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagrelide is by means of Decreased Platelet Production.		PDE
T10667	Calmidazolium chloride	R 24571	CaMK , Autophagy
	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 ...		CaMK , Autophagy
T1083	Theophylline	Theo-24,1,3-Dimethylxanthine	Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy
	Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3...
T8787	Drotaverine hydrochloride		PDE
	Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela...		PDE